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Whole-genome sequencing in the epidemiology of Campylobacter jejuni infections

posted Mar 15, 2017, 1:24 AM by Mirko Rossi   [ updated Mar 15, 2017, 1:25 AM ]
Llarena AK, Taboada E, Rossi M. J Clin Microbiol. 2017 Mar 1. pii: JCM.00017-17. doi: 10.1128/JCM.00017-17

This review provides the current state of knowledge on the application of whole-genome sequencing (WGS) in the epidemiology of Campylobacter jejuni, the leading cause of bacterial gastroenteritis worldwide. We describe how WGS has increased our understanding of the evolutionary and epidemiological dynamics of this pathogen and how WGS has the potential to improve surveillance and outbreak detection. We have identified hurdles towards the full implementation of WGS in public health settings. However, despite these challenges, we believe that ample evidence is available to support the benefit of integrating WGS in the routine monitoring of C. jejuni infections and outbreak investigations.